Otx2-PNN Interaction to Regulate Cortical Plasticity
نویسندگان
چکیده
منابع مشابه
Otx2-PNN Interaction to Regulate Cortical Plasticity
The ability of the environment to shape cortical function is at its highest during critical periods of postnatal development. In the visual cortex, critical period onset is triggered by the maturation of parvalbumin inhibitory interneurons, which gradually become surrounded by a specialized glycosaminoglycan-rich extracellular matrix: the perineuronal nets. Among the identified factors regulati...
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Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature forebrain. Genetic disruption of choroid-expressed Otx2 impacts these distant ci...
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The hippocampal complex and neocortex are both integrally important in memory function, in particular as regards memory for episodes and knowledge about the world that is derived from them. It is traditionally assumed that the role of the hippocampus is time-limited, after which retrieval of episodic memory depends only upon neocortical stores. A number of lines of evidence indicate that this t...
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A neural network model called LISSOM for the cooperative self-organization of a erent and lateral connections in cortical maps is applied to modeling cortical plasticity. After self-organization, the LISSOM maps are in a dynamic equilibrium with the input, and reorganize like the cortex in response to simulated cortical lesions and intracortical microstimulation. The model predicts that adaptin...
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It has been clear for almost two decades that cortical representations in adult animals are not fixed entities, but rather, are dynamic and are continuously modified by experience. The cortex can preferentially allocate area to represent the particular peripheral input sources that are proportionally most used. Alterations in cortical representations appear to underlie learning tasks dependent ...
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ژورنال
عنوان ژورنال: Neural Plasticity
سال: 2016
ISSN: 2090-5904,1687-5443
DOI: 10.1155/2016/7931693